PLOD1 and polycystic ovary syndrome: Letrozole administration in the PCOS group for 8 weeks resulted in a significant increase in serum LH, serum FSH, and serum testosterone compared to both control and P. dioscoridis groups, P < 0.05 (Fig 6A, 6B, 6C) (P = 0.05) (Fig 6C).