NFKB1 and necrotizing enterocolitis: Several studies have found that NNMT and its metabolite 1-MNA are elevated in a variety of inflammatory or injurious diseases and exert antifibrotic, anti-inflammatory [14], inhibit NF-κB pathway activity [13] and exert vasoprotective activity [29] Our findings of elevated NNMT and 1-MNA in NEC suggest a potential role for NNMT and 1-MNA in NEC.