CRELD1 and familial atrioventricular septal defect: The first of two was from our team in which we [11] reported an association of CRELD1 polymorphic haplotypes (rs9878047-rs3774207-rs73118372) with increased odds in favour of AVSD among DS individuals and, second one by Asim et al., 2018 [12], who reported a novel missense VCV001686602.1 variant in CRELD1 gene, to be exclusively present among individuals with DS and AVSD.