Interestingly, CA IX/XII targeting in prostate CAFs leads to a reduction of extracellular acidosis and tumor cells grown in presence of CA IX/XII‐inhibited CAF‐CM are characterized by decreased lactate uptake and enhanced ferroptosis sensitivity, confirming a potential role for extracellular pH in modulating lactate import by cancer cells and consequently in regulating ferroptosis. Here, CA9 is linked to cancer.