The L:R findings from NicheNet were visualized with Circos plots highlighting the differences in signaling (Figure 6E) and a network analysis of these findings demonstrated the centrality of BMP4/BMPR2 signaling in WT and BMP2/COL4A1/FN1 and loss of VEGFA signaling in PAH lung (Supplemental Figure 14). This evidence concerns the gene COL4A1 and pulmonary arterial hypertension.