CIS (15), SOCS2 (18), SOCS6 (45), PCMTD2 (46), and ASB2 (47–49) have known roles in regulating immune cell function and/or association with cancers, but the roles of ASB3, ASB6, WSB1, and LRRC41 in HSPCs are less understood. The gene discussed is CISH; the disease is cancer.