Of these, 46 were detected in the leprosy scRNA-Seq dataset (18), with elevated expression (z score >2) observed in endothelial cells (n = 8), fibroblasts (n = 6), keratinocytes (n = 9), myeloid cells (n = 15), and T cells (n = 8), indicating a broad effect of TNF across multiple skin cell populations during RRs. The gene discussed is TNF; the disease is leprosy.