Atrial fibrosis is induced by activated cardiac fibroblasts (CF), targeting CF activation has emerged as a potential therapeutic target for AF.[17, 18] Recent studies have shown that histone lactylation drives fibrotic progression in pulmonary diseases and cancer by activating lung fibroblast and tumor‐associated fibroblast proliferation.[19, 20] However, the role of histone lactylation in cardiac fibroblast activation in AF has not been investigated. Here, CFTR is linked to atrial fibrillation.