A “writer” enzyme crucially regulates epigenetic modifications by adding or importing specific modifications to substrate molecules, and its expression levels largely determine the rate of lactylation.[33, 51] Currently, it has been observed that the acetyltransferases P300, GCN5, and MOF may function as histone lactylation writers.[35, 36] By disrupting histone lactylation by silencing or inhibiting the writer, thereby suppressing the cellular proliferation and fibrosis capacity of CF under a high lactate environment. The gene discussed is EP300; the disease is cystic fibrosis.