Additionally, the regulator effect of glycolysis on global lactylation and H3K18la levels in both atrial tissue and fibroblasts isolated from atrial tissue was confirmed by AAV‐mediated overexpression and knockdown of atrial PFKM, establishing a direct mechanistic link between metabolic remodeling and epigenetic in AF pathogenesis (Figure S13A–D, Supporting Information). Here, PFKM is linked to atrial fibrillation.