Tumor volume correlated strongly with GR2 status (p = 3.5 × 10− 6) and histopathological markers of major grading criteria including mitotic count (p < 0.001), brain invasion (p < 0.05), and minor grading criteria including hypercellularity (p < 0.001), necrosis (p < 0.001) along with increased Ki67 index (p < 0.01). This evidence concerns the gene MKI67 and neoplasm.