The production of ROS by NOX3 may be related to deafness, and knocking out NOX3 can alleviate noise‐induced hearing loss.[45, 46] Cisplatin can induce the expression of NOX1 and NOX4 in the HEI‐OC1 cell line, and NADPH oxidase inhibitors can reduce cisplatin‐induced ROS generation and apoptotic cell death.[47] However, other NOX family members in the cochlea have not been well studied. This evidence concerns the gene NOX4 and hearing loss disorder.