Known as a stress‐responsive cytokine, GDF15 is notably elevated under reductive stress conditions.[104] Studies have demonstrated that cells forced into a reductive state show pronounced increases in GDF15 expression.[105] Elevated GDF15 has also been observed in patients with mitochondrial disorders, conditions typically associated with reductive stress.[104, 106] These findings suggest that analogous metabolic signatures might be sought in cancer or other diseases characterized by reductive stress. This evidence concerns the gene GDF15 and cancer.