Nevertheless, the Mn‐enrichment may influence the development of obesity through selective modulation of specific endocannabinoid mediators in the gut, particularly NAEs, such as PEA and OEA, are known to exert anti‐inflammatory and anorexigenic effects through activation of PPAR‐α and inhibition of feeding behavior. This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.