ALOX15B and neoplasm: Notably, treatment with methyl protodioscin (MPD), a steroid saponin primarily purified from polygonatum sibiricum rhizome, restored the S‐palmitoylation and membrane location of ALOX15B via disruption of the ABHD17C/ALOX15B interaction, consequently resulting in significant inhibition of growth rate of patient‐derived KRASmut‐PDAC organoids in vitro and KRASmut‐PDAC‐formed tumor in vivo via induction of ferroptosis.