NES and Huntington disease: It is interesting to note that both HD mouse models and HD patients have reduced levels of PDE10A as well as reduced levels of FOXP1.[68, 69, 70] Given that Pde10a is a Foxp1 target and is decreased in both Nestin‐Cre (Foxp1‐/‐) and Foxp1± mice, it is reasonable to hypothesize that reduced Foxp1 expression may also be responsible for the reduced striatal Pde10a levels in HD.