We confirmed that the super potency and selectivity of TAZA and TAM were associated with activation of IFN signaling, as supported by the high‐level secretions of IFN‐α (Figure 5L, 3–104‐fold promotions) and IFN‐β (Figure 5M, 4–7‐fold promotions) in the culture medium of PBMCs harvested from relapsed rather than diagnosed AML patients. Here, IFNB1 is linked to acute myeloid leukemia.