Since the common action of HMAs and ATRA is to trigger IFN anticancer immune response, albeit one at the upstream DNA demethylation step[1, 2, 3] and the other at the intermediate dsRNA sensing step,[33, 34, 35] a possible explanation for such a coincidence is that AML is a cancer type that is particularly susceptible to IFN immune response. This evidence concerns the gene IFNA1 and acute myeloid leukemia.