IFNA1 and acute myeloid leukemia: HMAs were reported to induce DNA hypomethylation and upregulate endogenous viral dsRNA, which was sensed by dsRNA sensors, triggering IFN anticancer immune response in various solid tumors.[1, 2, 3] This DNA hypomethylation‐dsRNA overloading‐IFN signaling is recapitulated in HMA‐treated AML in the current study (Figure6, first two panels).