The driver genes involved in the pathogenesis of H. pylori-related GC are the virulence factors, namely, Cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin gene A (VacA).58 Overexpression of CagA in transgenic mice induced gastrointestinal neoplasms, confirming its function as a bacterial oncoprotein.59 A comparative analysis in transgenic mice of CagA isoforms from Western and East Asian countries showed that western CagA-ABC is less oncogenic than E. Asian isoform ABCCC-type CagA. This evidence concerns the gene S100A8 and digestive system neoplasm.