The virus must evade the immunosurveillance to undergo primary replication at the site of infection before viral dissemination.88,89 Viral propagation within the GI district is presumed to be linked to the higher expression of the Angiotensin-Converting Enzyme 2 (ACE2) receptors on the surface of the enterocytes.90–95 A recent study, led by Chakraborty and colleagues, showed that the SARS-CoV-2 strategy to evade immunity is through NLRP3 inflammasome inhibition. This evidence concerns the gene NLRP3 and infection.