Moreover, EBV and H. pylori co-evolution altered the expression of the tumor suppressor retinoblastoma protein (pRB), the phosphatase and tensin homolog (PTEN) protein, the oncoprotein gankyrin, the antiapoptotic B-cell leukemia/lymphoma 2 protein (Bcl2) and the tumor protein Tumor protein P53 (p53), critical for enhanced carcinogenic activity.78 This information may support the development of targeted therapeutic strategies for preventing or treating gastric cancer associated with these infections. This evidence concerns the gene TP53 and gastric cancer.