The only known tumor formation study in RALA knockdown pancreatic cancer cells (CFPac-1, HPAC, Capan1) reconstituted with WT-RALA versus S194A-RALA phosphodeficient mutant showed loss of RALA to affect tumor formation that is restored by WT-RALA reconstitution. The gene discussed is RALA; the disease is familial pancreatic carcinoma.