Along with factors such as CRP, PCT, IL-6, and white blood cell (WBC), we compared and analyzed the potential of resistin and S100A8/A9 as biomarkers for diagnosing sepsis, predicting mortality, generating survival curves, identifying Gram-negative bacteria (G-) and Gram-positive bacteria (G+), and immune subtype identification. The gene discussed is S100A8; the disease is Sepsis.