Resistin, another key pro-inflammatory cytokine (Bostrom et al., 2009; Johansson et al., 2009; Singbartl et al., 2016), plays a crucial role in metabolic inflammation and atherosclerosis, with human resistin expression increasing under inflammatory pathological conditions (Macdonald et al., 2014; Rachakonda et al., 2014; Macdonald et al., 2017). The gene discussed is RETN; the disease is atherosclerosis.