Among sepsis patients admitted to the ICU, the AUC for S100A8/A9 in predicting 28-day mortality was 0.617 (P = 0.032; 95% confidence bounds 0.513–0.721), and for SOFA was 0.750 (P < 0.0001; 95% confidence bounds 0.660–0.840). Here, S100A8 is linked to Sepsis.