We found that (1) ApoER2 is highly expressed by a subset of amygdala neurons; (2) multiple ApoER2-Dab1 pathway components accumulate within abnormal neurons and neuritic plaques in the amygdala in MCI and AD; and (3) ApoER2-Dab1 pathway markers correlate with hallmark plaques and tangles, cognition, and neuropsychiatric manifestations of AD. Here, DAB1 is linked to Alzheimer disease.