We next sought to explore whether the extent of accumulation of ApoER2-Dab1 pathway components in amygdala correlated with the presence or extent of the neurobehavioral endpoints in the NACC Uniform Data Set: behavior, comportment, and personality (Form B4, Item 9); personality change (Form B9, Item 9g); behavioral symptoms (Form B9, Item 8); and depression (Form B6, Item 16; GDS-15). This evidence concerns the gene LRP8 and major depressive disorder.