The expression of Dab1, pP85αTyr607, pLIMK1Thr508, pTauSer202/Thr205, and pPSD95Thr19 increased across the clinicopathological spectrum of AD and positively correlated with Braak stage, Aβ plaque load, CAA score, and antemortem cognitive deficits (Fig 2B, 3B), with particularly strong associations observed for pP85α (Fig 2B), pTau (Fig 3B), and pPSD95 (Fig 3B). The gene discussed is DAB1; the disease is Cognitive impairment.