Single-target IHC revealed that five neuronal ApoER2 signaling partners (Dab1, pP85αTyr607, pLIMK1Thr508, pTauSer202/Thr205, pPSD95Thr19) accumulated in MCI and AD cases and positively correlated with histological progression and antemortem cognitive deficits (Figs 2–3). The gene discussed is LRP8; the disease is Cognitive impairment.