Since Reelin signaling through ApoER2 induces proteasomal degradation of Dab1 (reviewed in [25, 27]), the observed combination of extracellular Reelin deposition and neuritic Dab1 accumulation in hippocampus implies that disruption of Reelin binding to ApoER2 in hippocampus may play a role in AD pathogenesis. Here, LRP8 is linked to Alzheimer disease.