RELN and Alzheimer disease: Our previous work showed prominent neuritic plaque-associated deposition of Reelin in the molecular layer of the dentate gyrus and cornu ammonis in most (but not all) AD cases.[27] Unexpectedly, however, despite using the same reagents and methods on corresponding amygdala specimens, we did not find evidence for Reelin accumulation in the amygdala in any of these same AD cases.