In amygdala, the extent of accumulation of all seven ApoER2-Dab1 pathway markers that were significantly elevated in AD—ApoER2, Dab1, pP85αTyr607, pLIMK1Thr508, pTauSer202/Thr205, pPSD95Thr19, and ApoJ—correlated with deficits in comportment. This evidence concerns the gene LRP8 and Alzheimer disease.