Spatial transcriptomics revealed that several key findings are specifically localized to the non-caseating granulomas, including CD4+ T-cell-dominated infiltrates, the presence of plasma cells with local immunoglobulin production, the expression of IFNγ and its inducible genes, and the production of IL1B, TNF, and TGFB1 (Supplementary Figure 16). The gene discussed is TNF; the disease is Granuloma.