IL1B and Granuloma: Spatial transcriptomics revealed that several key findings are specifically localized to the non-caseating granulomas, including CD4+ T-cell-dominated infiltrates, the presence of plasma cells with local immunoglobulin production, the expression of IFNγ and its inducible genes, and the production of IL1B, TNF, and TGFB1 (Supplementary Figure 16).