TRPC1 and metabolic syndrome: Notably, endothelial TRPC1 deficiency exacerbated these lipid abnormalities under obese conditions: DIO-TRPC1EC−/− mice displayed significantly increased levels of TC, LDL-C, and TG, along with further reductions in HDL-C compared to DIO-TRPC1fl/fl mice (Figures 2C–F), indicating exacerbated dyslipidemia.