Mechanistically, lncRNA220 regulates apoptosis and autophagy in LPS-treated KCs through the PI3K-AKT-mTORC1 pathway and the miR-5101/PI3K/AKT/mTOR axis, suggesting that lncRNA220 may serve as a molecular target with clinical, diagnostic, and therapeutic implications in septic acute liver injury (103, 104). This evidence concerns the gene AKT1 and dry eye syndrome.