On the other hand, type I interferons (IFN-α/β) significantly promote TANs polarization toward an anti-tumor phenotype by activating the Fas/FasL pathway, inducing apoptosis-related genes in pro-tumor TANs, and upregulating effector molecules such as NO, H2O2, and TNF (98, 99). This evidence concerns the gene FASLG and neoplasm.