summarised the role of apoptosis, pyroptosis, and necroptosis in AD and highlighted that several molecules involved in PANoptosis, such as AIM2, CASP8, CASP1, RIPK3, and MLKL, have been identified as key players in neuroinflammation and neurodegenerative diseases, including AD (9). The gene discussed is AIM2; the disease is Alzheimer disease.