A recent study highlighted that VTN, along with other proteins involved in extracellular matrix organization, belongs to a cluster of molecules that are significantly upregulated only in patients with COVID-19 with fatal pneumonia compared to those with severe pneumonia requiring intensive care unit (ICU) admission and those with pneumonia not requiring ICU admission (58). Our data showed that, although the two groups of PLWH showed activation of the coagulation and complement cascades, coinfection with SARS-Cov-2 resulted in differences in the expression of associated factors. This evidence concerns the gene VTN and pneumonia.