CASP1 and diabetic kidney disease: Moreover, Tan IIA also inhibited pyroptosis in HRGEC cells by inhibiting the activation of the NLRP 3 inflammasome.; Salidroside suppresses activation of NLRP 3 inflammasome involving Caspase-1, thereby alleviating high glucose-induced ECM deposition in mouse mesangial cells; paclitaxel, a bioactive compound derived from Taxus, alleviates DKD in palmitate-induced damage in podocytes by reducing the expression of TGF- β1 (170).