The criteria included obesity (WC ≥ P90), TGs ≥ P90, HDL-C ≤ 10th percentile [P10], BP (systolic blood pressure [SBP] or diastolic blood pressure [DBP] ≥ P90), and glucose (insulin ≥ P90 or fasting plasma glucose [FPG] ≥ P90). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.