SIRT2 and tuberculosis: However, a few proteins appeared to be differentially abundant between TB and TB-DM, such as a cluster of six proteins (interleukin-18 receptor 1 [IL-18R1], osteoprotegerin [OPG], adenosine deaminase [ADA], IL-17C, fibroblast growth factor 23 [FGF-23], and sirtuin-2 [SIRT2]), which was especially elevated in TB-DM (Figure 1B).