In TB-DM, the proteins osteoprotegerin (OPG), signaling lymphocytic activation molecule (SLAMF1), adenosine deaminase (ADA), interleukin-10 receptor subunit beta (IL-10RB), and tumor necrosis factor receptor superfamily member 9 (TNFSR9) were differentially abundant, and IL-17A/C predicted treatment failure. Here, ADA is linked to diabetes mellitus.