The primary objective of this study is to assess the over expression of five lncRNAs, namely, Opa interacting protein 5 (OIP5), colon cancer-associated transcript-1 (CCAT1), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), maternally expressed gene 3 (MEG3), and urothelial cancer associated 1 (UCA1) in the tissue and plasma of oral squamous cell carcinoma (OSCC) patients and correlation of this expression and response to radiation therapy. This evidence concerns the gene UCA1 and oral cavity squamous cell carcinoma.