The primary objective of this study is to assess the over expression of five lncRNAs, namely, Opa interacting protein 5 (OIP5), colon cancer-associated transcript-1 (CCAT1), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), maternally expressed gene 3 (MEG3), and urothelial cancer associated 1 (UCA1) in the tissue and plasma of oral squamous cell carcinoma (OSCC) patients and correlation of this expression and response to radiation therapy. The gene discussed is OIP5; the disease is oral cavity squamous cell carcinoma.