NF1 and plexiform neurofibroma: The 2021 consensus diagnostic criteria for NF1 require at least two of the following: six or more café-au-lait macules, axillary or inguinal freckling, two or more neurofibromas or one plexiform neurofibroma, optic glioma, two or more Lisch nodules, a distinctive osseous lesion, a first-degree relative with NF1, or a confirmed pathogenic NF1 variant by genetic testing [4].