Importantly, both central stem and anchor bnAb lineages were elicited in humans upon seasonal influenza vaccination, followed by either a chimeric HA (cHA) or H1 stabilized stem ferritin nanoparticle (H1ssF) vaccine; NCT03300050 and NCT03814720, respectively22,23, suggesting their clinical relevance in anti-influenza immunity. This evidence concerns the gene TCFL5 and influenza.