Because elevated activation of the cGAS-STING pathway has been associated with peripheral T-cell lymphomas (51) and we found the Top3b-KO mice to be immune-compromized, we used a lymphoma syngeneic model (Fig. 6A) and compared tumor development in Top3b-KO and WT mice. The gene discussed is TOP3B; the disease is peripheral T-cell lymphoma, not otherwise specified.