LMNA and Hutchinson-Gilford progeria syndrome: Aberrant splicing choices caused by pathogenic mutations are implicated in numerous diseases, highlighting the clinical significance of RNA processing dysregulation.18,19 A notable example is Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder caused by a de novo heterozygous 1824C>T point mutation in the LMNA gene, which encodes the nuclear structural proteins lamin A and C.20,21 The disease-causing mutation activates a cryptic splice donor site within LMNA, leading to the production of progerin, a defective variant of lamin A lacking 50 crucial amino acids.