ZNF207 and Hutchinson-Gilford progeria syndrome: Importantly, knockdown of ZNF207 in HGPS patient-derived fibroblasts leads to a significant reduction in progerin protein levels (Figure 3E), despite its well-documented stability.70,71 Notably, this effect, akin to the changes in LMNA splicing levels, is reversed upon reintroducing an siRNA-resistant ZNF207 ORF into the cells (Figure 3E).