Progerin expression disrupts nuclear envelope morphology and impacts key epigenetic markers, such as H3K27me3 and H4K16ac, alongside reduced levels of lamina-associated polypeptide 2α (LAP2α) and Lamin B1 (LB1).71–74 The overall phenotype observed in the HGPS patient-derived fibroblasts was relatively mild (Figure S5H). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.