An interesting observation is that two proteins, PI3K delta isoform (PIK3CD) and phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) in this module are also involved in the PI3K signaling pathway, which is critical for cell survival and frequently altered in ovarian cancer. The gene discussed is PIP4K2A; the disease is ovarian cancer.