For example, glutamate ionotropic receptor AMPA type subunit 2 (Gria2) was found decreased in AD patients [51], and Gria1 was also altered in the 3xTg mice with NF-α1/CPE treatment, (Fig S1) suggesting the role of AMPA subunit in the pathogenesis of AD. This evidence concerns the gene GRIA2 and Alzheimer disease.