More in-depth analysis between organ specific metastases revealed upregulation of the transcription factor hes family BHLH transcription factor 2 (HES2) in lung vs breast, the p53 degrader ubiquitin D (UBD) in liver vs breast and the preferentially expressed antigen of melanoma (PRAME) gene in liver vs lung, which has been observed in metastatic breast cancers (Figure S7B) (67). Here, HES2 is linked to melanoma.