HES2 and breast cancer: More in-depth analysis between organ specific metastases revealed upregulation of the transcription factor hes family BHLH transcription factor 2 (HES2) in lung vs breast, the p53 degrader ubiquitin D (UBD) in liver vs breast and the preferentially expressed antigen of melanoma (PRAME) gene in liver vs lung, which has been observed in metastatic breast cancers (Figure S7B) (67).