CD4 and neoplasm: These approaches independently uncovered two distinct immune niches: Niche 1 contains CD4+ and CD8+ T cells, alveolar macrophages, macrophages, and diverse DCs; surprisingly, these sites containing the T cells shown above to be the major producers of IFN-γ were associated with small proliferative lesions rather than cellular dormancy; conversely, Niche 2 was enriched in CD103+ cDCs, NK cells, NKT cells, and monocytes/neutrophils (Supp Figure S6D and S6E) and associated with true tumor cell dormancy.