They suggest a model in which a subset of metastatic tumor cells able to be rapidly induced to dormancy by IFN-γ upon seeding to the lung (possibly produced at a distance by activated CD8 T cells) escape destruction by nearby NK cells, whereas those tumor cells that avoid induction of dormancy by IFN-γ proliferate but are kept as small proliferating lesions by persistent cytotoxic action of the colocalized CD8 T cells. The gene discussed is CD8A; the disease is neoplasm.