Using NetMHCpan as a prediction algorithm, we selected five ADRD-associated risk proteins (i.e., APP, MAPT, TARDBP, FUS, SNCA) that have pathologic SNPs that lead to the development of AD, frontotemporal lobe dementia (FTLD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease, or Lewy body dementia (LBD). This evidence concerns the gene TARDBP and semantic dementia.