PTGS2 and neoplasm: Genes Ptgs2, Cxcl1, Vegfa, Cxcl2, Col1a1 and Col1a2 were downregulated in cluster 0 of the A101 CAR-T-treated tumor compared to the mock-T-treated group which are involved in angiogenesis and tumor-promoting inflammation as well as EMT and tumor progression (Fig. 8e) [23, 24] [25].