Despite the line-to-line response differences in p21WAF1 expression (Figure 1B and 2A), IL-6 secretion (Figure 2B), γ-H2AX levels (Figure 2C) and p16INK4A expression (Figure 2C), all 4 NSCLC cell lines showed an increase in cellular senescence upon siRNA knockdown of SRSF3, which was supported by both increased SA-β-gal-positive cells (Figure 1C) and reduced cell proliferation (reduced Ki67-positive cells, Figure 1D). Here, IL6 is linked to non-small cell lung carcinoma.