These data suggest that the induction of cellular senescence may be a common outcome of the SRSF3 knockdown in NSCLC cells, which can be induced through one or more pathways involving the CDK inhibitors p21WAF1 and/or p16INK4A, DNA damage response, and pro-inflammatory SASP cytokines (32). The gene discussed is SRSF3; the disease is non-small cell lung carcinoma.