Our analysis of public datasets and gene expression assays (Figure 5 and Supplementary Table 1) suggest that SRSF3 knockdown-induced senescence in NSCLC cells may be mediated by downregulation of TOP2A, ASPM and UBE2C, which all are known to act oncogenic in lung carcinogenesis (19,24,25) and whose high expression levels are significantly associated with poor prognosis (Supplementary Figure 1). Here, SRSF3 is linked to non-small cell lung carcinoma.