To directly test whether the upregulated p53β in these NSCLC cells contributes to the SRSF3 knockdown-induced senescence, we transduced A549, H1975 and H322 cells, along with U-87 MG glioblastoma cells as a control, with a constitutive lentiviral vector that drives the overexpression of p53β, which corresponds to the TP53 status of each transduced cell line, i.e., wild-type p53β for A549 and U-87 MG, and mutant p53β at codon 273 or 248 for H1975 or H322, respectively (Figure 4B). Here, TP53 is linked to non-small cell lung carcinoma.