However, in contrast to the induction of cellular senescence by overexpression of p53β in normal human fibroblasts (15), human CD8+ T lymphocytes (14) and a glioblastoma cell line U-87 MG (Figure 4C; and N. von Muhlinen et al., in preparation), no increase in senescent cells was observed in any of the NSCLC cell lines overexpressing p53β (Figure 4C), suggesting that p53β is not a major effector of SRSF3 knockdown in NSCLC cells. This evidence concerns the gene CD8A and glioblastoma.