Promyelocytic leukemia (PML) nuclear bodies (PML-NBs) recruit various cellular proteins and are comprised of numerous constitutively and transiently associated proteins (Van Damme et al, 2010) that function in a vast array of cellular processes, including, but not limited to, senescence, regulation of chromatin structure and gene expression, the ubiquitin pathway, the DNA damage response, and the innate immune response to viral infection (Scherer & Stamminger, 2016). This evidence concerns the gene PML and viral infectious disease.