ERBB2 and liver cancer: Major Facilitator Superfamily Domain Containing 4A protein (Mfsd4a) involved in glucose transmembrane transport is on the top list of dysregulated genes, and is down-regulated 16-fold in Srsf3 KO Erbb2 breast cancer, but up-regulated 293-fold in DEN-induced Srsf3 KO liver cancer (Figure 4B).