Consistently with Erbb2 cancer tissues, knockdown of Srsf3 expression in mouse Erbb2+ NF639 cells and two human breast cancer cell lines ER+ MCF7 and HER2+ SKBR3 cells was also found to promote exon 11 inclusion of Eif4a2 (Figure S10D) and subsequently to inhibit the production of eIF4A2 protein (Figure S10E). The gene discussed is SRSF3; the disease is cancer.