By Venn diagram analysis (Figure 4A), we identified 41 genes commonly responsive to Srsf3 KO, with 15 genes significantly downregulated in breast cancer but upregulated in liver cancer, and 9 genes significantly upregulated in breast cancer but downregulated in liver cancer upon Srsf3 KO (Figure 4B)., The remaining 17 genes were common Srsf3 KO responders, of which 4 genes were upregulated and 13 genes were downregulated, including Srsf1, by Srsf3 KO in both Erbb2 breast cancer and DEN-induced liver cancer (Figure 4A). This evidence concerns the gene SRSF1 and breast cancer.