Although the difference in Srsf3 KO-induced gene expression profiles identified above were notable and most likely resulted from the different organs (breast vs liver) and different carcinogens used in the tumor induction, we wanted to investigate the common Srsf3-responsive genes and to explore how Srsf3 plays its opposite roles in the development of Erbb2 breast cancer and DEN-induced liver cancer. The gene discussed is ERBB2; the disease is breast carcinoma.