Our RNA-seq and RT-qPCR analyses of DEN-induced Srsf3 WT and Srsf3 KO liver cancer show significant reduction of Lifr and Egfr expression, but increased expression of oncogenic Myc (54) in DEN-induced Srsf3 KO liver cancer in both male and female mice (Figure 5E and 5F, Figure S12B). The gene discussed is EGFR; the disease is liver cancer.