Although Srsf3 KO had no effect on the expression of Sox4, E2f1, Trpv4, and Trim6 in the Srsf3 KO Erbb2 breast cancer when compared to the Srsf3 WT Erbb2 breast cancer (Figure 2A–2D), we discovered that Srsf3 KO increased the expression of Sox4, E2f1, Trpv4 and Trim6 expression in DEN-induced liver cancer when compared to DEN-induced Srsf3 WT liver cancer (Figure 2E–2H). This evidence concerns the gene E2F1 and breast cancer.