RT-PCR analyses of the total RNA from Erbb2 breast cancer and DEN-induced liver cancer tissues and Western blot analyses of the tissue lysates from the Erbb2 breast cancer and DEN-induced liver cancer tissues, respectively, confirmed Srsf3 KO increasing the exon 11 inclusion of Eif4a2 mRNA and decreasing the eIF4A2 protein production in the Erbb2 breast cancer (Figure 4E), but promoting the exon 11 exclusion of Eif4a2 and increase the production of eIF4A2 protein in the DEN-induced liver cancer (Figure 4F). The gene discussed is ERBB2; the disease is breast carcinoma.