Consistently with Erbb2 cancer tissues, knockdown of Srsf3 expression in mouse Erbb2+ NF639 cells and two human breast cancer cell lines ER+ MCF7 and HER2+ SKBR3 cells was also found to promote exon 11 inclusion of Eif4a2 (Figure S10D) and subsequently to inhibit the production of eIF4A2 protein (Figure S10E). Here, ESR1 is linked to cancer.