Causative variants for CHD have been identified in a diverse set of genes known to coordinate early cardiac development, including those for cardiac transcription factors (TFs) such as NKX2-5, TBX5, TBX20 and GATA45–9, intercellular signalling intermediates such as NOTCH, NODAL, SMAD and RAS proteins, as well as cilial proteins10–14, epigenetic regulators4,15–20 and structural proteins3. Here, NKX2-5 is linked to coronary artery disorder.