CRP and Shock: In univariate logistic regression analysis, nosocomial acquisition, malignancy, corticosteroid use, central venous catheter, prosthetic heart valve, persistent fever (>72 hours), prolonged bacteremia (≥3 days), septic shock, pneumonia, endocarditis, bone infection, arteriovenous graft infection, C-reactive protein (CRP) ≥10 mg/dL, and prolonged antibiotic treatment (>6 weeks) were significantly associated with metastatic infection (Table 2 and Supplementary Table 3).