BRCA1 and breast carcinoma: Considering our estimates of the probability of BRCA1/2 carriers developing ovarian cancer (p15) and breast cancer (p16) until age 70, which are significantly lower than lifetime rates reported in other studies, we explored three scenarios (Table 3): increasing p15 to 0.202, increasing p16 to 0.644, and increasing both p15 to 0.202 and p16 to 0.644.