Lower serum PAPP-A levels were found in pregnancies after IVF and ICSI and higher serum fβhCG levels in non-male factor infertility at 11-14 wk of gestation. Serum PAPP-A was lower in ART pregnancies with “female factor infertility” (0.93, p < 0.009) and in ART pregnancies with “male factor infertility” (0.87, p < 0.005). It is important to determine whether fβhCG MoM values should be corrected for non-male factor infertility, as it is best to avoid the high false positive rate in this group. Here, PAPPA is linked to Infertility.