Our study found a significant association between the mutant T allele in HMMR-rs299295 (A485V) and the mutant G allele in STAB2-rs2271637 (L2401V) variants and an increased risk of prostate neoplasm, including both groups (BPH, prostate cancer) compared to control men. Here, STAB2 is linked to benign prostatic hyperplasia.