Based on the identified molecular and functional associations of HMMR and FAM83D with mitosis, we proposed that the HMMR-rs299295 missense variant encourages prostate neoplasm and progression by enhancing cell cycle progression via binding with HMMR and FAM83D. STAB2-rs2271637 is a missense variant of the STAB2 gene, encoding a protein that functions as a receptor for HA. This evidence concerns the gene HMMR and prostate neoplasm.