AQP4 and epilepsy: Previous studies have mainly investigated the effects of factors involving inflammation (GORTER et al., 2015), sleep issues (Reddy and VAN DER Werf, 2020), AQP4 abnormalities (LOHELA et al., 2022), glutamate excess, and glutamate receptor hyperactivation (GORTER et al., 2015; DADAS et al., 2016) after epilepsy.