AQP4 and temporal lobe epilepsy: The current study suggests that seizures may be linked to impaired water clearance caused by AQP dysfunction, specifically AQP4(BONOSI et al., 2023), and Ayushe et al. (SHARMA et al., 2023) and Isabella et al. (GIACHETTI et al., 2022) have also found evidence of increased free water in the onset brain region in studies of patients with temporal lobe epilepsy.