Since Mn2+ has great potential for activating the cGAS‐STING signaling pathway to generate antitumor immune responses, Team Haisheng reported that microneedles loaded with sparfloxacin and Zinc-Manganese sulfide nanoparticles could significantly suppress tumor growth, thereby significantly enhancing the tumor infiltration and cytotoxic effects of CD4+/CD8+ T cells and strongly inhibiting the lung metastasis of TNBC cells (76). Here, CD4 is linked to neoplasm.