SETD2 and neoplasm: Additionally, in mouse models deficient in SETD2—a histone methyltransferase that catalyzes H3K36 trimethylation—tumorigenesis is promoted due to the inhibition of the SIRT1/FOXO signaling pathway, highlighting SIRT1’s role downstream of SETD2 in regulating tumor progression (Feng et al., 2023).