Regarding NF-κb, there is a study counted 261 CRC tissue samples, analyzed the relationship between NF-κb and CRC by immunohistochemical method, and found that the expression of NF-κb was significantly correlated with the expression of SIRT1 and SNAIL, a marker of EMT (Pyo and Kim, 2019). Here, SIRT1 is linked to colorectal carcinoma.