TP53 and colorectal carcinoma: These studies have shown that CRC cells undergo apoptosis through three signaling pathways after treatment with SIRT inhibitors: the SIRT1/P53 pathway via deacetylation (Ghosh et al., 2017), the c-Jun N-terminal kinase (JNK) pathway and its downstream regulated caspases (Kang et al., 2022b), and the Fas/FasL pathway (Kang et al., 2022b).