SIRT1 and colorectal carcinoma: Additional studies have also suggested that SIRT1 exerts an inhibitory effect on CRC, with a focus on its role in tumorigenicity and metastasis (Sun et al., 2017; Harada et al., 2016; El-Kott et al., 2021), and its potential as a drug target (García-Martínez et al., 2023; Jung et al., 2015).