SIRT1 and cancer: They found that the high expression of SIRT1 was statistically significantly correlated with the proliferation status of GC, advanced cancer stage (Jiang et al., 2016; Mohammadi Saravle et al., 2018), poor overall survival (OS) (Otsuka et al., 2023), recurrence free survival (Qiu et al., 2016), and increased number of metastatic lymph nodes (Cha et al., 2009; Noguchi et al., 2014).