Numerous investigations have analyzed tissues and EC cell lines from EC patients, particularly those with esophageal squamous cell carcinoma (ESCC), revealing that high SIRT1 expression is associated with advanced TNM stage (Ha et al., 2018), poor prognosis (He et al., 2016), lymph node metastasis (Yan et al., 2020), inferior overall survival (Ma MC. This evidence concerns the gene SIRT1 and esophageal squamous cell carcinoma.